Discriminating coding and non-coding RNAs using comparative sequence analysis

In my talk, I will first briefly review challenges and the current state-of-the-art for genome-wide annotation of non-coding RNAs. To accurately locate non-coding RNAs in a genome it turned out to be critical to know what parts are actually coding. Although there are many sophisticated protein gene finders and very good annotations exist for most model organisms, there are also ambiguous and non-standard situations in which these programs fail.